Science  ·  Quality  ·  Compliance  ·  Commitment
Specialized Contract Research Organization

Laboratory Testing &
Regulatory Excellence

Teleios Analytical Services is a provider of laboratory testing and expert regulatory advisory services for Pharmaceutical and Medical Device companies — supporting every stage from discovery through lifecycle management.

"Every test we do in perfection while keeping up the patients' health and safety to provide quality products."

E&L Studies Nitrosamine & NDSRIs FDA · EMA · ICH LC-QTOF · GC-MS · ICP-MS USP <232> <467> <665> IND · NDA · ANDA Support
Testing Services

Comprehensive Analytical
Capabilities

We offer all testing needs during discovery, characterization, product development, drug & medical device approvals, and lifecycle management.

01 / 08

Characterization Studies

Supporting product development of INDs, NDAs, and ANDAs with comprehensive characterization testing.

  • Drug Substance (API) testing — assay, impurities, residual solvents, polymer screening & particle size analysis
  • Excipients Screening and Selection
  • Pre-formulation Studies — Solubility, Stability & Excipient Compatibility
  • Forced Degradation Studies of APIs and Drug Products
  • Assay & Related Substances Testing of Drug Substance in the drug product
  • Stability studies during development
02 / 08

Analytical Method Development, Validation & Transfers

Robust analytical techniques for pharmaceutical products, medical devices, dietary supplements, and cosmetics.

ICH Q2R(2) USP <1224> USP <1225> USP <1226> EMA Guidelines

Our experienced team develops robust analytical techniques through review of chemistry of intermediates, raw materials, drug substances, packaging materials, and drug product formulations using Quality by Design principles.

We support analytical method validations and/or verification as per ICH, USP, EMA, and other regulatory requirements — covering prescription and OTC pharmaceuticals, medical devices, dietary supplements, and cosmetics.

03 / 08

Process Equipment-Related Leachables (PERLs)

Evaluating Single Use Systems (SUS) and manufacturing process components.

USP <665> USP <1665> BOPG Guidance

Manufacturing processes use components partly or fully constructed from plastic polymeric materials — commonly Single Use Systems (SUS). These components contact manufacturing process streams from starting materials through the finished drug product.

Such contact can lead to the release of extractables (PERLs) that persist in the process stream, accumulate in the drug product, and potentially affect product quality and patient safety.

Teleios' experienced team evaluates your process components, assesses associated risks, proposes controls, and prepares a complete risk assessment report in compliance with USP<665>, USP<1665>, or BOPG Best Practices guidance.

04 / 08

Extractables & Leachables (E&L) Studies

End-to-end E&L study design, execution, and toxicological risk assessment.

Extractables are substances that can be extracted from pharmaceutical packaging materials, biomedical devices, or drug delivery systems. Leachables migrate from container closure systems under normal use conditions — typically present at trace levels but posing significant risk to patients.

Our team designs, develops, and executes forced Extractable studies using a stepwise approach — considering the intended final use and Maximum Daily Dose (MDD) — and generates complete data with toxicological risk assessment in line with USP and ICH regulations.

  • Volatile & Semi-volatiles — Headspace GC-MS
  • Non-volatiles — LC/MS
  • Metals — ICP/MS
  • Leachable method development & quantification
  • Complete toxicological risk assessment reports
05 / 08

Nitrosamine & NDSRI Impurity Testing

Highly sensitive nitrosamine testing compliant with FDA, EMA, and ICH M7 guidelines.

Nitrosamines are potent genotoxic impurities that require careful monitoring across pharmaceutical products. Our advanced instrumentation allows detection and quantification at the lowest possible levels — well below regulatory acceptable intake limits.

We provide full NDSRI (Nitrosamine Drug Substance-Related Impurities) testing, risk assessment, and regulatory-ready reports aligned with evolving FDA and EMA requirements.

06 / 08

Genotoxic Impurity Testing

Trace-level detection aligned with ICH M7 and regulatory thresholds of toxicological concern.

Genotoxic impurities present unique analytical challenges due to the very low levels at which they must be controlled. Our LC-QTOF and GC-MS/MS platforms enable sensitive, specific detection of potential genotoxic compounds in drug substances and drug products.

We provide method development, validation, and testing per ICH M7 with full documentation suitable for regulatory submissions.

07 / 08

Unknown Impurity Characterization

High-resolution mass spectrometry–driven structure elucidation of unknown peaks.

When unexpected impurity peaks appear in your chromatograms, Teleios provides comprehensive characterization using our high-resolution LC-QTOF platform for accurate mass measurement and structural elucidation.

Our scientists combine non-targeted analysis, database searches, and chemical reasoning to identify unknowns and provide risk-based assessments — enabling informed decisions about your manufacturing process and product quality.

08 / 08

Packaging Testing

Container closure system testing for compatibility, safety, and regulatory compliance.

USP <232> USP <467> USP <665> ISO 10993

Packaging materials must be rigorously tested to ensure they do not compromise product quality or patient safety. Teleios performs comprehensive testing of primary and secondary packaging components, including glass, plastics, rubber closures, and combination products.

Our testing programs are designed to meet USP <232>, <467>, <665>, and ISO 10993 requirements, with full documentation for regulatory submissions.

Why Teleios

Built for speed,
precision & compliance

Our customers are our strength, and our customer goals are our goals. We combine state-of-the-art instrumentation with direct scientist-to-client communication — eliminating the bottlenecks common in large CROs. Whether you're a biotech startup or global pharma, Teleios scales with you.

Faster & More Accurate Testing

Advanced LC-QTOF, GC-FID/MS, and ICP-MS instrumentation. Direct scientist-to-client communication eliminates delays and interpretation gaps.

Regulatory Compliance First

Full adherence to FDA, EMA, ICH, USP, and ISO guidelines — minimizing risk and accelerating your market entry at every stage.

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Cost-Effective & Scalable

Flexible solutions for startups and large pharma alike — from early-phase formulations through commercial production.

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Regulatory-Ready Reports

Our target is to provide regulatory compliance reports that meet FDA, EMA, and ICH requirements — ready for submission without rework.

Who We Serve

Partners across the life sciences spectrum

From emerging biotechs navigating first IND filings to established manufacturers managing complex global supply chains, Teleios provides the analytical depth your regulatory strategy demands.

Pharmaceutical Companies
Biologics & Biosimilars Manufacturers
Medical Device Companies
Food & Beverage Industry
Drug Substance / API Manufacturers
Packaging Material Suppliers
Biotech Startups
Contract Manufacturers (CMOs)
Instrumentation

Cutting-Edge Analytical Platforms

LC-QTOF
Liquid Chromatography Quadrupole Time-of-Flight MS
High-resolution non-targeted analysis — ideal for unknown impurity characterization, E&L studies, and trace-level detection of leachables and nitrosamines.
GC-FID/MS
Gas Chromatography with Flame Ionization / Mass Spectrometry
Volatile & semi-volatile extractables, residual solvents, headspace analysis of packaging materials and process equipment.
ICP-MS
Inductively Coupled Plasma Mass Spectrometry
Elemental impurity analysis per USP <232> and ICH Q3D — trace metals in drug substances, drug products, and packaging materials.
Contact Us

Let's discuss your next project

Teleios brings specialized expertise, cutting-edge instrumentation, and a compliance-first mindset to every engagement. Reach out and we'll get back to you promptly.

Email info@teleios-labs.com
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Address 1 Maple Street
Milford, MA 01757
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